Guardian Technologies Glucose Monitor manual Reduce glycemic variability and HbA1c levels

Reduce glycemic variability and HbA1c levels

using continuous glucose monitoring vs. fingersticks alone

The revolutionary Guardian® RT system gives patients the benefits of continuous glucose monitoring in REAL-Time, around the clock. Continuous glucose monitoring is proven to improve patient outcomes versus fingersticks alone by reducing glycemic variability and HbA1c levels.2-5

More meaningful insights than fingersticks alone

Reduces HbA1cs and related complications

• Reduces long-term diabetes complications: Continuous glucose monitoring has been shown to help guide

therapy adjustment leading to reductions in HbA1c levels versus the use of fingersticks alone2-4

Fingersticks taken 4 times only give you part of the picture*

Fingersticks alone

16.7

mmol/L-	11.1
Glucose	5.6
		Target zone
	0

• Measures glucose levels continuously: Just as the systems of a human

body monitors glucose levels to guide insulin release, continuous

glucose monitoring measures glucose 24 hours a day giving patients

meaningful insights to help guide therapy decisions

• HbA1c testing and fingersticks alone provide less meaningful insights

because they do not monitor glucose levels continuously

— HbA1c testing is performed at a single point in time, once every

2 to 3 months and produces an average blood glucose level

— Fingersticks also measure glucose levels at a single point in time —

patients test on average 4 to 5 times per day

— Each 1% reduction in HbA1c reduces the risk of long-term complications like eye, nerve, kidney and heart

disease by 15% to 30%7,12

REAL-Time alarms helped reduce the	Continuous glucose monitoring
duration of hypoglycemic excursions10	reduces HbA1cs

3:00 AM 6:00 AM 9:00 AM 12:00 PM 3:00 PM 6:00 PM 9:00 PM

Time of day

Continuous glucose monitoring

completes the picture

Continuous glucose monitoring

16.7

Highs missed by these fingersticks

- mmol/L	11.1
Glucose	5.6
		Target zone
	0	Lows missed by these fingersticks

3:00 AM 6:00 AM 9:00 AM 12:00 PM 3:00 PM 6:00 PM 9:00 PM

Time of day

• REAL-Time continuous glucose monitoring provides updated glucose

readings every five minutes — up to 288 glucose measurements per

day — to alert patients to take action sooner2-5

Better detects hypoglycemia and hyperglycemia for more proactive patient self-management

•Identifies hidden variability: Continuous glucose monitoring helps reveal dangerous glucose variability that may not be tracked by fingersticks alone and HbA1c testing6

—60% of lows may not be revealed when using fingersticks alone.9,11 HbA1c testing provides a 2 to 3 month average of glucose levels and isn’t intended to track highs and lows6

—Continuous glucose monitoring identifies up to 4 times more glucose excursions requiring therapy adjustment versus fingersticks alone, so patients can intervene more quickly3

P = 0.03

Patient response to REAL-Time alarms resulted in a 48% reduction in mean duration of hypoglycemic excursion, from 64.4 minutes to 33.6 minutes

(P = 0.004).5 Patients in the control group, withoutREAL-Time alarms, experienced no significant change

Continuous glucose monitoring vs. fingersticks4

	9.0
	8.5		Fingersticks alone
			CGM
% ± SE	8.0
	7.5
HbA1c,
	7.0
		P = n.s.	P = .011
	6.5
	6.0
	Start	6 weeks	12 weeks

By helping to reduce HbA1c levels, continuous

glucose monitoring helps to reduce the risk of long- term complications and increase a patient’s lifespan7

* Chart is illustrative of a patient taking 4 fingersticks in one day, at times shown.