Check for good ground connection.
Check that remote DC terminal has at least 3v DC.
Check that there is battery power on the + terminal.
Check all fuses.
Check that Protection LED is not lit. If it is lit, shut off amplifier briefly and then repower it.
Disconnect all RCA inputs to the amplifier(s) - if hiss/noise disappears, then plug in the component driving the amplifier and unplug its inputs. If hiss/noise disappears, go on until the faulty/noisy component is found.
It is best to set the amplifier’s input level as low as possible.The best subjective S/N ratio is obtainle this way.Try drive as signal level from the head unit as possibe.
Check for shorts on speaker leads.
Check that the volume control on the head unit is turned down low. 
Remove speaker leads,and reset the amplifier. If the Protection LED still comes on, then the amplifier is faulty.
Check that the minimum speaker impedance for that model is correct.
Check for speaker shorts.
Check that there is good airflow around the amplifier. In some applications, an external cooling fan may be required.
Check that the Level control(s) is set to match the signal level of the head unit.
Check that all crossover frequencies have been properly set. 
Check for shorts on the speaker leads.
This is almost always caused by a 232 specifications
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