Agilent Technologies G1978B setup guide Changing Sources, To remove the multimode source

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Installation 1

Changing Sources

Changing Sources

To remove the multimode source

Do the following steps to remove the multimode source.

1Set the source temperatures for vaporizer heater and drying gas heater to minimum values to cool the source.

Use the Tune > Instrument > Edit Spray Chamber menu item to display the Edit Spray Chamber dialog box. Set the drying gas flow, nebulizer gas flow, drying gas temperature and the vaporizer temperature to minimum values.

WA R N I N G

Do not touch the multimode source or the capillary cap. They may be very hot. Let

the parts cool before you handle them.

 

 

 

 

Never touch the source surfaces, especially when you analyze toxic substances or

WA R N I N G

when you use toxic solvents. The source has several sharp pieces which can pierce

 

 

your skin including the APCI corona needle, vaporizer sensor and counter current

 

electrode.

 

 

 

Do not insert fingers or tools through the openings on the multimode chamber. When

WA R N I N G

in use, the capillary and capillary cap are at high voltages up to 4 kV.

 

 

 

 

 

2

Wait approximately 20 minutes or until the source is cool.

 

3

Open the CDS door at the front of the MS to access the cables.

 

4

Disconnect the ESI high voltage charging electrode cable.

 

5

Disconnect the APCI Needle Interlock and multimode HV cable.

 

6

Unscrew the nebulizer gas line from the nebulizer.

 

7

Unscrew the LC sample tubing from the nebulizer.

 

8

Open the latch on the source and open the source.

 

9

Remove the multimode source from the spray chamber mount.

Multimode Source for 6100 Series Single Quad LC/MS Set-Up Guide

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Contents Set-Up Guide U T I O N WA R N I N G This Guide Page Content Contents Installation Prepare to install InstallationFrom left to right G1946-80058, G1960-60802 and G1960-60856 Install the HV control PCA and cablesConnecting the valve PCA to the multimode HV power supply Connecting the Vcap and Vchamber cables to the power supply Connecting the HV PCA to the chassis To remove the multimode source Changing SourcesTo convert from multimode to ESI, Apci or Appi To convert from ESI, Apci or Appi to the multimode source Installation onStandard spray shield and capillary cap for ESI or Apci T E Multimode Spray Chamber No nebulizer on top of the multimode source LC/MS sample tubing connected to LC/MS inlet filter Verification Preparation 6110 and 6120 Quad Performance Verification Summary Table 6140 Quad Performance Verification Summary, SIM Mode 20 1 pk-pk 10 1 pk-pk Verification 6140 Quad Performance Verification Summary, Scan Mode 6130SCNESMM.M 6130SCNCIMM.M Verification Create and run a Multiple FIA Method Sequence Verification Autotune report To do an autotuneExample of multimode verification report Example of multimode verification report Methods Be impaired and the system may catch fire To setup a method to use the multimode sourceMethods Polarity options for Signal 1 and Signal Method Spray Chamber set to MM-ES+APCI To create a method for alternating ESI and Apci operationIonization mode for Signal 1 and Signal Index Index Page G1978-90070

G1978B specifications

Agilent Technologies G1978B is a high-performance mass spectrometer that is widely recognized for its innovations in analytical chemistry. This instrument stands out due to its combination of advanced technologies that enhance sensitivity, accuracy, and precision for complex analyses.

One of the key features of the G1978B is its compatibility with various ionization techniques, including Electrospray Ionization (ESI) and Atmospheric Pressure Chemical Ionization (APCI). This versatility allows users to analyze a diverse range of sample types, from small molecules to large biomolecules. Each ionization technique has its unique advantages, making the G1978B an excellent choice for laboratories focusing on pharmaceuticals, environmental analysis, and proteomics.

The G1978B is equipped with a sophisticated quadrupole mass filter, ensuring high-resolution mass measurements. This technology provides excellent mass accuracy and reproducibility, enabling users to distinguish between closely related compounds with minimal interference. The advanced data acquisition systems incorporated in the G1978B allow for rapid scanning capabilities, making it particularly effective for high-throughput screening applications.

In addition, the instrument features an intuitive user interface that simplifies method development and operational tasks. This includes streamlined software solutions that facilitate data analysis and interpretation, ensuring that even complex datasets can be managed efficiently. Furthermore, built-in diagnostic tools help in monitoring instrument performance, significantly reducing downtime and enhancing productivity.

The G1978B also incorporates advanced technologies for enhanced sensitivity. Its innovative source design minimizes background noise while maximizing signal intensity, making it particularly valuable for the detection of trace-level contaminants or low-abundance metabolites. Coupled with its exceptional dynamic range, the G1978B can quantify analytes over several orders of magnitude, which is crucial for applications in toxicology and clinical research.

With a robust design and ease of integration into existing laboratory workflows, the Agilent G1978B provides an ideal solution for researchers seeking a reliable mass spectrometry platform. Its combination of advanced ionization techniques, high-resolution capabilities, and user-friendly software makes it a versatile tool in modern analytical laboratories, paving the way for breakthroughs in research and development across a multitude of scientific disciplines.
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